Decitabine 5-aza-2'-deoxycytidine CAS 2353-33-5:

Product Name:Decitabine
Synonyms:4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on;
5-AZA-CDR; 5-Aza-2'-deoxycytidine
CAS No:2353-33-5
Molecular Formula: C8H12N4O4
Moculer weight: 228.21
EINECS:219-089-4  

Appearence: White to Off-white powder 

COA: can be requested

Storage condition: keep in seal, cool and dry place

Stability: Stable. May be light or air sensitive. Incompatible with strong oxidizing agents.

Cyproterone acetate has antagonistic properties towards the 5-Aza-2'-Deoxycytidine, has been reported to cause phosphorylation inhibition of 2'-deoxycytidine in certain cells and the incorporation of 2'-deoxycytidine into DNA. Experiments have shown that this compound induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits Dnmt (DNA methyltransferase). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2'-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, this agent demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase 2.

COA of Decitabine 5-aza-2'-deoxycytidine CAS 2353-33-5:

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